Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review

Background Local immunosuppression in vascularized composite allotransplantation (VCA) aims to minimize immunosuppressant-related toxic and malignant side effects. Promising allograft survival data have been published by multiple workgroups. In this systematic review, we examine preclinical animal studies that investigated local VCA. Material methods We conducted a review of manuscripts listed the MEDLINE PubMed database concerning VCA models. Papers included had be available as full-text written English. Non-VCA studies, human trials, using cell-based therapy strategies were excluded. followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Results Literature research retrieved 980 articles. Ten between 2010 2019 met inclusion exclusion criteria. Seven out ten articles demonstrated significant prolongation immunosuppression. Five employed tacrolimus (TAC) main immunosuppressive agent. performed hind-limb rat model. Conclusion The easily accessible location skin containing VCAs makes it an ideal candidate Published are very promising terms improved reduced systemic toxicity.